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Other than warfarinno formal drug-drug interaction studies between XELODA and other CYP2C9 substrates have been conductedCare should be exercised when XELODA is coadministered with CYP2C9 substrates.

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In both trialsoverall survivaltime to progression and response ratecomplete plus partial responseswere assessedResponses were defined by the World Health Organization criteria and submitted to a blinded independent review committeeIRCDifferences in assessments between the investigator and IRC were reconciled by the sponsorblinded to treatment armaccording to a specified algorithmSurvival was assessed based on a non-inferiority analysis.

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furthermore, the group that received the ixempra xeloda combination had a progression-free survival rate of 4. al rate of 4.

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