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There is also the possibility that a patient who is treated with REVIA could overcome the opioid blockade effect of REVIAAlthough REVIA is a potent antagonistthe blockade produced by REVIA is surmountableThe plasma concentration of exogenous opioids attained immediately following their acute administration may be sufficient to overcome the competitive receptor blockadeThis poses a potential risk to individuals who attempton their ownto overcome the blockade by administering large amounts of exogenous opioidsAny attempt by a patient to overcome the antagonism by taking opioids is especially dangerous and may lead to life-threatening opioid intoxication or fatal overdosePatients should be told of the serious consequences of trying to overcome the opioid blockadesee PATIENT INFORMATION

REVIA has fewif anyintrinsic actions besides its opioid blocking propertiesHoweverit does produce some pupillary constrictionby an unknown mechanism.

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