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In cases of multiple sclerosisImuran is generally taken orallyin the form of tablets.

Particular care should be taken to monitor haematological response and to reduce the maintenance dosage to the minimum required for clinical response.

Information is available on the risk of malignancy with the use of IMURAN in rheumatoid arthritissee ADVERSE REACTIONSIt has not been possible to define the precise risk of malignancy due to IMURANThe data suggest the risk may be elevated in patients with rheumatoid arthritisthough lower than for renal transplant patientsHoweveracute myelogenous leukemia as well as solid tumors have been reported in patients with rheumatoid arthritis who have received IMURAN.

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