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Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions.

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Chloroquine is very rapidly and completely absorbed after ingestionToxic doses of chloroquine can be fatalAs little as 1 g may be fatal in childrenToxic symptoms can occur within minutesThese consist of headachedrowsinessvisual disturbancesnausea and vomitingcardiovascular collapseshock and convulsions followed by sudden and early respiratory and cardiac arrestHypokalemia has been observed with arrhythmias in cases of intoxicationThe electrocardiogram may reveal atrial standstillnodal rhythmprolonged intraventricular conduction timeand progressive bradycardia leading to ventricular fibrillation and/or arrestCases of extrapyramidal disorders have also been reported in the context of chloroquine overdosesee WARNINGS and ADVERSE REACTIONS

The blood concentrations of chloroquine and desethylchloroquinethe major metabolite of chloroquinewhich also has antimalarial propertieswere negatively associated with log antibody titersChloroquine taken in the dose recommended for malaria prophylaxis can reduce the antibody response to primary immunization with intradermal human diploid-cell rabies vaccine.

Because of the potential for serious adverse reactions in nursing infants from chloroquinea decision should be made whether to discontinue nursing or to discontinue the drugtaking into account the potential clinical benefit of the drug to the mother.

Take the missed dose as soon as you remember itHoweverif it is almost time for the next doseskip the missed dose and continue your regular dosing scheduleDo not take a double dose to make up for a missed one.

ARALEN does not prevent relapses in patients with vivax or malariae malaria because it is not effective against exoerythrocytic forms of the parasitenor will it prevent vivax or malariae infection when administered as a prophylacticIt is highly effective as a suppressive agent in patients with vivax or malariae malariain terminating acute attacksand significantly lengthening the interval between treatment and relapseIn patients with falciparum malaria it abolishes the acute attack and effects complete cure of the infectionunless due to a resistant strain of Pfalciparum

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however, the seroconversion rate among those taking chloroquine was still adequate, and the volunteers in morocco and nepal were not taking chloroquine. chloroquine.

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